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Introduction
In the RSalute segment, page 50 of Italian Repubblica November 8 2018, I read that :
The saliva of a small group of e-cigarette users contained increased levels of three DNA-damaging compounds according to a research made in BIrmingham. David Ticket in Birmingham says that the products of heated polypropylene glycole in e-juice, have toxic effects on the immune system alvaeolar macrophage in the lungs.
Thes chemicals are formaldehyde, acrolein and methylglyoxal
They do not tell what kind if eliquid was used. Most people have some kind of flavour in the juice. Flavours have been a issue before.
The article also says “The most concerning findings were related to acrolein, which is produced when glycerol is heated”
Index
- Introduction
Propylene glycole (PG) molecule - Chemical reaction with PG
- Diacetile – popcorn lungs
- Lipoid pneumonia
- Conclusion
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Propylene glycole (PG) molecule
Propylene glycole looks like this:
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Chemical reaction with PG
With the heat in the coil tea ch propylene glycole moelcule loose three hydrogen atoms and you get a Acrolein molecule and three water molecules.
transforms into
acrolein molecule
+
two water molecules
mage sources: ( Wikipedia and www.vectorstock.com )
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Diacetile – popcorn lungs
a friend of mine informed me abiout a site telling about http://www.vanniveronesi.com/1/sigarette_elettroniche_un_polmone_al_popcorn_per_favore_10721525.html . This page gives a link that makes you maybe land on https://ehp.niehs.nih.gov/doi/10.1289/ehp.15101 where they say: “There are > 7,000 e-cigarette flavors currently marketed. Flavoring chemicals gained notoriety in the early 2000s when inhalation exposure of the flavoring chemical diacetyl was found to be associated with a disease that became known as “popcorn lung.”
This study looked for Diacetyl (2,3-butanedione) in 51 e-juice flavours. Peach schnapps cocktail had the highest concentration of Diacetyl (P238 μg/e-cigarette) in the vapor and aerosol of ecig. ( Source: table 2 ehp.niehs.nih.gov/ ) They give value e-cigarette but does not tell what a “e-cigarette” means . It looks like the e-cigarette is a cartridge they used. However they “drew air through the e-cigarette for 8 sec at a time, with a resting period of 15 or 30 sec between each draw”. They probably did this automatically with a computer led air pump to get comparable tests.
I found this video about “popcorn lungs”. They talk Italian informing about diacetile.
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Lipoid pneumonia
I hear a few years ago about lipoid pneumonia. I pressumed that these vapers must have been vaping a lot. But no studies seem to have been done to measure the quantities of PG and/or VG in the vapour andf how much they vaped.
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Conclusion
The acrolein study done so far is incomplete. There are several questions that have not been studied
- What kind of liquid did the vapers use?
PG or VG with aroma and nicotine or not? - They only found it in the saliva.
- Non studies have been done to measure acroleine density in the lungs
- Where there acrolein in the vape or only in the liquid and in what quantities?
- How could acrolein reach the lunggs?
- How much PG reach the lungs? (to know more about lipid pneumonia riscs.
How do we get aacroleine oer diacetile into the lungs”. it should remain in the juice or as these are not hydrophiles (weater soluble)
liek PG is with its OH groups. Some PG may reach the lungs
